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(PubMed) Why adding GIP matters In simplified terms: GLP-1R activation contributes to satiety and delayed gastric emptying GIPR activation can influence insulin secretion and broader metabolic signalling Clinical literature discusses tirzepatides dual activity and associated weight-loss outcomes, with adverse effects broadly similar to GLP-1RA class GI patterns

Doubling the dose at one time significantly increases the likelihood of GI side effects without proportional benefit and is not supported by any trial data

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Siegel RL, Giaquinto AN, Jemal A

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1-Year comparative effectiveness of tofacitinib vs ustekinumab for patients with ulcerative colitis and prior antitumor necrosis factor failure