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Despite their established glucose-lowering effects, there is no consensus among global experts and modern guidelines regarding the priority of SUs in relation to other therapeutic options, given the lack of evidence that SUs are associated with a low risk of macrovascular events and excess mortality

Studies have shown that allulose can attenuate postprandial blood glucose levels, reduce insulin requirements, and even suppress hunger-associated feeding by inhibiting hunger-promoting neurons in the hypothalamic arcuate nucleus (ARC)

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