glp 1 study Another milestone in the evolution of GLP-1-based diabetes therapies Current Insights, Advantages and Challenges
Description
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Sequential initiationadding one agent, allowing 48 weeks for tolerance to develop, then introducing the secondmay improve tolerability, particularly regarding gastrointestinal side effects from GLP-1 receptor agonists
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Most people notice changes in their appetite within the first two weeks

Indeed, as shown in Supple

Focus on metformin-a major cardiovascular medication