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When transitioning a patient from semaglutide to tirzepatide, the starting dose may vary depending on the previous semaglutide dose and the patients side effect profile

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If you or a family member have a history of medullary thyroid carcinoma, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), Tirzepatide is not recommended due to an increased risk of thyroid tumors

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Never overlap both medications Taking semaglutide and tirzepatide simultaneously is not recommended by any clinical guideline

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