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Metabolism 63:919 Del Olmo-Garcia MI, Merino-Torres JF (2018) GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes
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Indeed, SU-based compounds have been shown to uncouple the glucose dependence of GLP-1R agonist activity in the rat pancreas [96]
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We speculate this could potentially explain the absence of reduced risk for PDAC associated with GLP1RA-related weight loss in contrast to weight loss following bariatric surgery 45
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