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Hepatoportal leptin sensors and their reflex effects on autonomic outflow in the rat

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In the brain, the PVN contains different neuronal populations related to appetite regulation, stress response, and other neuroendocrine functions [132,238], one of the neuronal populations linked to satiety signaling express GLP-1 receptors [132]

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This means that even if the solution appears normal, it may not deliver the intended glucose-lowering or weight management effects