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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)

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Future Research Goals So far, most evidence comes from retrospective studies or case reports, not from large randomized clinical trials, says Tariq, who says that experts are still looking to understand: Whether GLP-1s directly reduce intestinal inflammation How GLP-1s interact with the immune system and the gut microbiome Whether they are as effective in people with active Crohns disease as with those in remission Current research findings show promise, but Tariq encourages her patients to view them as early signals instead of established treatments

GLP-1 receptor agonistsmedications such as semaglutide and liraglutidehave gained attention for their weight management properties, though they were originally developed for type 2 diabetes

When you combine a fiber-rich diet with semaglutide, your meals can be smaller and simpler (e.g