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Besides, dual GLP-1/GIP receptor agonists (DA-JC4, DA5-CH, DA-JC1 and DA-CH3) reduced inflammation response, amyloid plaques and tau phosphorylation in brain, reversed memory loss, and enhanced synaptic plasticity in hippocampus of APP/PS1 mice (186, 234, 236, 238)

Furthermore, these medications contribute to improved metabolic health and may lower the risk of cardiovascular diseases

MR, YYW, and JXZ drafted the manuscript

Impacts of glucagon-like peptide-1 receptor agonists on the risk of adverse liver outcomes in patients with metabolic dysfunction-associated steatotic liver disease cirrhosis and type 2 diabetes

Since they had clinical resources, they were uniquely positioned to stand up their own weight management program