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Effects of GLP-1 Receptor Agonists on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus: A 52-Week Clinical Study

6 In adolescents with obesity, first-generation GLP-1RAs such as liraglutide (Saxenda ) and semaglutide (Wegovy ) have shown significant reductions in body mass index (BMI) and improvements in metabolic parameters
Development of new therapies for the treatment of diabetes continues to focus on enhancing the positive effects of GLP-1

Substitution with Tyr 13 scarcely affects the activity of GIP (114) analogues, 33 implying that the use of Tyr 13 in the designed dual agonist may not conspicuously affect GIP activity
