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Semaglutide enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner, meaning these effects occur primarily when blood glucose levels are elevated
In contrast, native endogenous glucagon-like peptide-1 (GLP-1), extracted from human and porcine gut on the basis of reactivity with antibodies, turned out to be potently insulinotropic in a perfused pancreas preparation [28]
Diabetologia (2006) 49:25360
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