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This slow-and-steady approach is essential for supporting patient comfort and adherence

Dehydration and electrolyte imbalance may also play a role

Deamidation converts asparagine residues to aspartate, changing the charge profile of the molecule

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doi:10.1038/s41591-023-02597-w

Supplementation with magnesium glycinate (200 to 400 mg at bedtime) serves double duty