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It is generally safe to take both antidepressants and a GLP-1 medication, says Asha Shajahan, MD, a primary care provider with Corewell Health in Rosewell, Michigan

A potential side effect of these medications is slower gastric emptying meaning your stomach takes longer to release food into the intestine

Compounded versus brand-name considerations Many people use compounded semaglutide and compounded tirzepatide from pharmacies like Empower Pharmacy or other compounding sources

Alzheimers Dement (2016) 12(6):71932

Gastrointestinal events, mainly mild-to-moderate nausea, were more common with oral semaglutide than with placebo