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In the open method, esophagojejunostomy of PG-DTR or TG involved anastomosis between the esophageal stump and the proximal jejunum using a circular stapler

ME/CFS CLinician Coalition) (2020)

Injections can rapidly increase B12 levels, making them ideal for those with absorption challenges or needing immediate results

Maintenance treatments may be recommended periodically to sustain the desired results, but these are typically less frequent than the initial treatment series and can help prolong the effects for even longer

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The timeline varies by injury severity, with acute injuries responding faster than chronic conditions that have been present for months or years