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They discovered that the anti-inflammatory and antioxidant properties of gallic acid decrease tissue iron concentration, improve mitochondrial damage, inhibit the P2X7-ROS signaling pathway, and reverse behavioral changes in these rats (Yang et al., 2023) (Table 1)

doi: 10.1097/MCO.0000000000000511

Factors such as stress, poor diet, illness, and sun exposure accelerate this depletion leaving skin looking dull, uneven, or prematurely aged