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Dose adjustments may be necessary when initiating or discontinuing concomitant medications

Khan FY, Yousif AB, Suliman A, Saleh AO, Magdi M, Alshurafa A, Hassan EA, Ghazy A, Salameh OK, Abdallah A (2021) Association of vitamin B12 deficiency with metformin use in patients with type 2 diabetes treated in the largest tertiary care hospital in Qatar

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This is relevant, as platelets are the first cells that arrive at a site of injury to release various factors that initiate the repair process

Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism