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Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan Tel: +81-22-717-8117, Fax: +81-22-717-8118, E-mail: [email protected] Copyright 2024 Korean Endocrine Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

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254 Another meta-analysis that included data from 371 NAFLD patients participating in five randomized controlled trials found liraglutide significantly reduced BMI, especially in those with co-occurring type 2 diabetes, but its lowering effects on liver fat and ALT levels were not statistically significant

It is also important to ensure that improvements in bioavailability are accompanied by comprehensive evaluations of pharmacological efficacy and safety to provide better therapeutic outcomes for cardiovascular diseases