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Cobalamin forms in plasma and tissue during treatment of vitamin B12 deficiency

Mechanistic summaries on this page are provided for laboratory reference and should be interpreted within controlled experimental settings only. In diet-induced obese (DIO) mice, treatment with 5-Amino-1MQ at 20 mg/kg/day for 11 days via subcutaneous injection reduced body weight by approximately 5.1%, epididymal fat pad mass by 35%, adipocyte size by more than 30%, and plasma cholesterol by 30%, with no changes in food intake or observable adverse effects (Neelakantan et al., 2017)

A serving of each will deliver close to the daily-recommended amount

The two compounds engage distinct mechanistic pathways

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The compound also enhances GLUT4 expression and promotes production of palmitic acid hydroxy stearic acids (PAHSAs), an alternative lipid class exhibiting anti-diabetic and anti-inflammatory properties