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For example, miR5325p, miR27a5p, miR30c5p, miR299, miR1423p, miR985p, miR3805p, miR133a3p, miR155, miR34a, miR181a, miR330, miR253p, and miR1270 have been shown to inhibit BACH1 mRNA level

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However, the inherent challenges of traditional animal-derived EVssuch as heterogeneity, scalability issues, and ethical concernshave driven researchers to explore more sustainable and safer alternativesPlant-derived extracellular vesicles (PDEVs) (Lian et al., 2022

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