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doi: 10.3389/fphar.2025.1656012 Received 29 June 2025 Accepted 17 September 2025 Published 30 September 2025 Volume 16 - 2025 Edited by Junmin Zhang, Lanzhou University, China Reviewed by Inamul Hasan Madar, Yenepoya (deemed to be University), India Leena Dhoble, University of Florida, United States Updates Copyright 2025 Liu, Ma, Chen, Gu, Sun and Li

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SLC38A3, another transporter of Gln, activates the PDK1/AKT signaling pathway and promotes the metastasis of NSCLC by regulating the transport of Gln and histidine, indicating that SLC38A3 owns consistent therapeutic potential for the treatment of NSCLC (43)

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Other systemic protein misfolding disorders, such as transthyretin (TTR) amyloidosis, further demonstrate how destabilization of otherwise soluble proteins can lead to pathogenic aggregation

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Recent studies have analyzed the structure of NF1, demonstrating that in addition to the GTPase domain, it contains a PH domain that interacts with SPRED protein to attach to the inner surface of the cell membrane [16,17,18]

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PK enzymes catalyze the final step in glycolysis: the irreversible transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of ATP (see Fig

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Previous hexavalent chromium toxicity studies also found exposure to 20 M chromium (VI) to result in eryptosis, together with Ca 2+ influx, increased ROS levels, and rapid ATP consumption

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