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Signs and symptoms include an enlarged thyroid gland, increased circulating thyroid antibodies (Thyroid Peroxidase antibody (TPOAb) or Thyroglobulin Antibodies (TGAb)), fatigue, weight gain, joint and muscle pain, dry skin and hair, heavy or irregular menstrual periods, fertility issues, constipation, and other symptoms associated with an under- or over-active thyroid

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10.1016/j.foodchem.2024.140747 [DOI] [PubMed] [Google Scholar] Iwasaki N, Kitajima S, Kuroda M

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These are called Circumventricular Organs (CVOs)