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Dissecting cellular mechanisms of Long-Chain Acylcarnitines-Driven cardiotoxicity: disturbance of calcium homeostasis, activation of Ca2+-Dependent phospholipases, and mitochondrial energetics collapse

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Randomized controlled trials demonstrate that periconceptional supplementation with folic acid (i.e., beginning one month before conception until the end of the first trimester) dramatically reduces the occurrence of NTDs

doi: 10.3389/fcell.2020.583850 Received 15 July 2020 Accepted 31 August 2020 Published 18 September 2020 Volume 8 - 2020 Edited by Vadivel Ganapathy, Texas Tech University Health Sciences Center, United States Reviewed by David Thwaites, Newcastle University, United Kingdom