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Not only was the regulation of the two step glutathione-synthetic pathway unevenly regulated, but the oxidation/reduction cycle of GSH/GSSG was also unbalanced in infested resistant plants

The context of pathway activation matters enormously

10.1016/0926-6917(95)90040-3 81 GoedertM

Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

For example, colonization of germ-free mice with Bacteroides thetaiotaomicron (191) or Escherichia coli Nissle 1917 (EcN) (192) led to up-regulation of genes encoding for proteins such as small proline-rich protein-2 (sprr2a) and ZO-1 involved in improving cellular adhesion