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Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses

NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

doi: 10.3389/fphys.2021.680544 Received 14 March 2021 Accepted 20 August 2021 Published 17 September 2021 Volume 12 - 2021 Edited by Karina Thieme, University of So Paulo, Brazil Reviewed by Nilberto Robson Falco Nascimento, State University of Cear, Brazil

In the same study, the genetic deletion in the oocyte of a specific enzyme Pdss2 (leading to its inactivation), involved in the CoQ10 synthesis led to aged oocytes in young mice with: Premature ovarian failure Reduction of follicle number Poor ovulation response to stimulation Decreased ATP production and mitochondrial activity in the few aged oocytes

J., Orskov, C., Nielsen, O

[DOI] [PubMed] [Google Scholar] Kuhn S, Zipfel PF