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Numerous researchers have found that individuals suffering from ME/CFS have a lower quality of life than people with other chronic illnesses, including multiple sclerosis (MS) (32), lung disease (33), rheumatoid arthritis (RA) (3335), and some forms of cancer (11, 33, 35)

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Meanwhile, the mechanism of action of natural metabolites can be studied in depth through network analysis (Zhou et al., 2024), molecular studies (Han et al., 2024)and animal modeling experiments to clarify their targets and signaling pathways at the cellular and molecular levels, which will provide a basis for the development of more effective therapeutic drugs

Therefore, the GSH/GSSG ratio is an important indicator of the cell redox state [15]

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A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease