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It is intriguing though, that despite the mild impact on L-carnitine levels, patients affected by these diseases have marked brain alterations such as nondysmorphic autism (deficiency of 6- N -trimethyllysine dioxygenase) [60] and microcephaly and speech delay (deficiency of -butyrobetaine dioxygenase) [61]

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it organizes into functional structure rather than disorganized scar tissue

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Similarly, tobacco exposure also resulted in a significantly higher mRNA expression of PARP, a marker of DNA damage and indicator of apoptosis, 43, 44 suggesting that the more extensive MI in tobacco-exposed rats is also accompanied by an increase in cardiomyocyte apoptosis