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3.4 Bioavailability and action targets The therapeutic potential of plant-derived antioxidants faces a significant challenge: their limited bioavailability (91, 153, 154)

BV biofilms are often resistant to antibiotics and can recur due to the existence of persister cells that have decreased metabolic activity and the physical barrier the biofilms create blocking antibiotics from accessing microbes within the extracellular polymeric substances, among other mechanisms 15,22,23

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In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

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