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However, while many drugs have been synthesized to target glutamine metabolism from its initial transport into the cell to its conversion to -KG, most are still in preclinical stages (Table 1) [44]

An early study demonstrated a protective effect of UA on spontaneous death of dopaminergic neurons in culture, with an antioxidant mechanism targeting Fe-produced reactive oxygen species 37

[] All steps of this study were prespecified, and the protocol was registered on PROSPERO (CRD42022333848)

Chung I, Osterwald S, Deeg KI, Rippe K (2012) PML body meets telomere

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F.NepachalovichP.PedreraL.ZilkaO.et al (2024)