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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Enechukwu CI, Onuegbu AJ, Olisekodiaka MJ, Eleje GU, Ikechebelu JI, Ugboaja JO, et al

This biological framework provides a plausible explanation for the strong and consistent associations observed between CTI and mortality across populations

We hypothesize that reduced CPT-I activity may contribute to persistent fatigue in these congenital hypothyroid patients, even after levothyroxine therapy, which alone may be insufficient to fully address the downstream metabolic consequences of TPO and TSHR gene mutations present in this cohort