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Hartleben B, Gdel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kbler S, et al

For clinicians, the desired effect is lowering IOP with a well-tolerated side effect profile. Given this proposed mechanism, Vyzulta is thought to lower IOP by increasing aqueous humor outflow through both the trabecular meshwork via nitric oxide, and the uveoscleral route via latanoprost, Dr

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The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14