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Functional research using hair depilation, hair shaving, and skin organoid models showed that HG cells first initiate mitophagy to eliminate mitochondria damaged potentially by apoptosis during catagen

Cartilage destruction is considered a hallmark of OA and is a result of increased production of catabolic effectors 32,33,34,35 and reduced matrix biosynthesis by chondrocytes 36

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In line with these considerations, an Nrf2-dependent increase in GCLC expression levels and activity was observed in tumors, in comparison with peritumoral tissues [308]

Zhang T, Zhang J, Shi J et al (2009) Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity

How can these three types of changes contribute to a clock