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doi: 10.1002/14651858.CD010223.pub2 202

Future research is needed to investigate the value of integrating these interventions with the established regimens of surgery, radiation, and chemotherapy

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In a further study, inhibiting HMGB1 levels in high glucoseexposed mesangial cells was found to restore cell proliferation, prevent ROS production, reverse ferroptosis, and reduce proinflammatory cytokine levels

Further evidence for this hypothesis comes from recent yeast two-hybrid studies performed with enzymes from sweet peony, where the arGST Ps GSTF3 was found to interact with Ps DFR, the dihydroflavonol reductase catalysing the formation of 3,4- cis -leucocyanidin ( 6 ) 47

Bilge et al., using a rat osteomyelitis model, noted improved histopathological parameters, suggesting ozone therapy has potent anti-inflammatory attributes [14]
