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However, skin retraction follows a different timeline: 0-8 weeks : Initial shrinking as pregnancy hormones decrease 3-6 months : Gradual improvement in skin elasticity 6-12 months : Maximum natural skin retraction usually achieved Beyond 12 months : Any remaining loose skin is unlikely to improve significantly without intervention Hormonal influences play a role during this recovery period

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A number of plant-derived agents, like genistein, quercetin, isoginkgetin, and epigallocatechin-3-gallate (EGCG), all contain isoflavone and isoflavone-like moieties in their structures, and have been shown to activate AMPK (Fig

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M., Vasiliu, D., Eremia, N