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This doesn't mean evening dosing is universally superior

Claire said: Some of the most common symptoms associated with vitamin B12 deficiency include feeling weak or fatigued, shortness of breath, appetite loss, headaches, mouth ulcers, digestive problems and feelings of mild depression

Age-related decline in gastric acid production and intrinsic factor availability may reduce the bodys ability to absorb oral B12 and other nutrients, making IM delivery a practical alternative

Andersson HC, Shapira E (1998)

Some of these strategies may be invasive (direct injection into the brain), but are ill-suited to chronic diseases such as MS