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A randomized, double-blind, placebo-controlled, phase III trial of erlotinib with or without a c-Met inhibitor tivantinib (ARQ 197) in Asian patients with previously treated stage IIIB/IV nonsquamous nonsmall-cell lung cancer harboring wild-type epidermal growth factor receptor (ATTENTION study)

In contrast, while full-length pVHL and the p19 variant interact with HIF-1, the association was abrogated by further N-terminal and C-terminal truncations

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Unlike traditional treatments like corticosteroids, biologics modulate the immune response with precision, effectively reducing inflammation and promoting mucosal healing while causing fewer systemic side effects [38]

[45] Collectively, the prolonged ROS sustain the harmful effects of hyperglycemia by epigenetic causes, chronic oxidative damage, and proinflammatory effects independent of the actual glucose level, contributing to the onset of diabetes