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2 S in pulmonary circulation, showing reduced H 2 S levels in lung tissues and plasma, along with inhibited expression and activity of cystathionine -lyase (CSE) in the pulmonary arteries and lung tissues of HPH rats ( 2 S donor significantly reduced PAP and mitigated pulmonary vascular remodeling ( 2 S inhibits the development of HPH, with downregulation of the H 2 S pathway identified as a key mechanism in its progression ( 2 S production contributes to the pathogenesis of HPH (Liu et al., 2012

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Hormonal variables are relevant to BPC-157 outcomes in women primarily in the context of perimenopause and menopause, where declining estrogen affects collagen synthesis rates and tissue healing capacity

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