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As senolytic research continues to evolve, FOXO4-DRI remains a key compound in studies focused on healthy aging, biological resilience, and regenerative medicine

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This activates the shikimate/phenylpropanoid pathway and enhances the accumulation of phenolics in vacuoles as a defensive mechanism

doi: 10.1186/s13020-021-00469-4 11 DaiL.XuJ.LiuB.DangY.WangR.ZhuangL.et al

The inhibition of AMPK further activates endoplasmic reticulum stress and the transcription factor XBP1s, ultimately leading to upregulation of PD-1 expression and impairing T cell immune function
