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It could also be the base fluid

doi: 10.1210/jc.2017-01210 52 HjelholtAJCharidemouEGriffinJLPedersenSBGudiksenAPilegaardHet al

For calculating reference memory, no platforms were set during the test
Preclinical studies using T4 (including the RGN-259 ophthalmic clinical trials) have not identified significant adverse events at therapeutic doses

Gastroenterology 146 , 726735 (2014)

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