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The state of chromatin is key in regulating gene expression and it is driven by two types of PTMs: (1) acetylation of lysine at the histone tail resulting in the activation of transcription and (2) methylation of lysine at the histone tail resulting in activation or repression of transcription depending on its position on the histone tail ( Despite a lack of knowledge regarding the exact mechanistic relationship between EDCs and epigenetic signatures, proposed mechanisms to date can be divided into two categories: gene-specific action and global action (Kouzmenko et al., 2010

doi: 10.1007/s11033-012-1893-4 126 BidHKKonwarRSaxenaMChaudhariPAgrawalCGBanerjeeM

In turn, PER and CRY bind to CLOCK and BMAL1 to inhibit their own expression

doi: 10.1016/j.jpsychires.2006.07.013 8 AslanlarD

A comparative study of wild-type (WT) and SR-knockout (SR-KO) mice revealed that the SR is involved primarily in D-serine production in the forebrain of mice, and that there might be other D-serine production pathways may be involved in the brain and peripheral organs (Horio et al., 2011)

Inflammation and neurodegeneration are normally associated in neurological conditions