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furthermore, exogenous NAD + impacts processes such as DNA replication 118

Uzel M, Akkin SM, Tanyeli E, et al

Pyruvate kinase deficiency is characterized by molecular as well as clinical heterogeneity

10.1172/JCI141833 10 BrownE

After incubation of cells with butein, there was an upregulation of markers downstream of these three proteins (phospho-eIF2, CHOP, ATF4, XBP1), including increased levels of IRE1 and phosphorylated PERK [186]
