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For instance, experimental studies that involve glutathione (Yamasoba et al., Figure 2 Consistent with this idea, glutathione, a tripeptide molecule (cysteine, glutamic acid, and glycine) and the most abundant endogenous free radical scavenger in humans, was the first antioxidant evaluated for the treatment of NIHL (Yamasoba et al., N-acetylcysteine (NAC), a cysteine precursor, is an antioxidant molecule that enhances the production of glutathione (Kopke et al., a replenisher of this endogenous scavenger (Kopke et al., Interestingly, recent evidence suggests that HK-2, a multifunctional antioxidant with a metal chelator and free radical scavenger properties (Kawada and Kador, Several micronutrients such as vitamins A, C, and E show antioxidant properties and have been used either individually or combined as experimental treatments for NIHL

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[DOI] [PubMed] [Google Scholar] 89.Townsend D.M., Tew K.D., Tapiero H

Diselenides Diselenides are characterized by the presence of a SeSe bond largely used in organic synthesis because of their accessibility through a number of different synthetic protocols and relative stability

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Matrix metalloproteinases are also upregulated in the lung after SM exposure, which are thought to contribute to the detachment of epithelial cells from basement membranes and disruption of the pulmonary epithelial barrier