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Fer-1 faces bioavailability and metabolic stability obstacles, with a notably short plasma half-life and imperfect penetration through the BBB, limiting its use in neurodegenerative conditions [99, 228, 229]

A key component in many of the astrocytic detoxification processes is the tripeptide glutathione (GSH) which serves as electron donor in the GSH peroxidase-catalyzed reduction of peroxides

L813-823

This approach sounded promising, but transplantation of bone marrow stem cell lines did not always lead to the desired results and was ineffective, resulting in potential harm to the patient

Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages