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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

For the T98G cell line, the overall trend was similar to the U87 cells

J Androl 23(6):737752 Aitken RJ, Whiting S, De Iuliis GN, McClymont S, Mitchell LA, Baker MA (2012) Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase

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Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trial
