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For example, functional studies of naturally occurring MC4R mutants (see Section V.B ) showed that the binding defective mutants are clustered in TM2, EL1, and TM3 (339), implicating this domain as important for ligand binding, consistent with data from previous site-directed mutagenesis experiments (330,331)

Binder, M., Kochs, G., Bartenschlager, R

Targeted Cancer Therapies: One Year of Progress

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