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Cell Host Microbe 14 , 582590 (2013)

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In aged animals, folic acid deficiency exacerbates the pro-inflammatory microglia response in a model of ischemic brain injury [68], thereby contributing to increased neuronal damage under folate-deficient conditions

However, these agents also affect normal healthy cells and induce various side effects, such as nausea, dizziness, fatigue, somnolence and insomnia

Accessed 14 Jan 2025 Ahmad S, Zafar I, Mariappan N, Husain M, Wei C-C, Vetal N, Eltoum IA, Ahmad A (2018) Acute pulmonary effects of aerosolized nicotine

Previous reports suggest that B 12 deficiency-associated dysfunction of methionine synthase reduces the availability of methionine and subsequently S-adenosyl-methionine, which is an important methyl group donor (Figure 2)