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* Correspondence: Mei Huang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM
Nat Microbiol 9(1):173184 Larabi AB, Masson HLP, Bumler AJ (2023Dec 31) Bile acids as modulators of gut microbiota composition and function

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Graphical abstract The above scientific illustration shows that, after intracellular polyglutamylation, Methotrexate induces oxidative stress in hepatocytes

They do not activate the GLP-1 receptor with the same potency, which means your expected dose effectively becomes a smaller dose
