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Targeting microglial -synuclein/TLRs/NF-kappaB/NLRP3 inflammasome Axis in Parkinson's disease

From a clinical and applied perspective, the evidence supports cycle-aware but non-dogmatic nutritional strategies, particularly in contexts of metabolic dysfunction, high training loads, or reproductive disorders

10.1126/science.aaa5004 10.1126/science.aaa5004 [DOI] [PMC free article] [PubMed] [Google Scholar] Zamora-Ros R, Forouhi NG, Sharp SJ et al (2013) The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study

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J Neuroinflamm (2019) 16:240

FOXO4-DRI functions as a competitive inhibitor, displacing p53 from FOXO4, thereby allowing the selective clearance of senescent cells (2, 9)
