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A cellular study has clarified that the methyl group brought inside cells by supplementation with MeCbl is not used in any methylation reactions and that supplementation with that form of B 12 does not produce more methionine as compared with supplementation OHCbl.25 The authors stated: Once released from the lysosomes, both MeCbl and OHCbl were converted in the same proportions to coenzyme forms, suggesting equivalent entry into common cellular pools of cobalamin from which active forms are synthesized

Br J Diabetes Vasc Dis 12(4):189193

An injectable form is considered far more effective than topical, as it works systemically and bypasses the top layer of the skin

The temporal association with starting B12 supplementation may simply reflect chance occurrence rather than causation

The peptides mechanism relies on sustained signaling to trigger lasting gene expression changes

The peptide was originally developed by researchers seeking to isolate the lipolytic effects of growth hormone from its other physiological actions