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doi: 10.1164/ajrccm.158.2.9710092

Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial

Nanobiotechnology 21 (1), 129

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This is primarily due to platelet activation during the blood collection process and is a known issue of concern with some eicosanoids (e.g., TxB 2 , 12-HETE)

Methods and results To test this hypothesis, we developed a rat model of hyperlipidemia induced by high-fat diet for 16 weeks, during which rats were treated with 1 mg/kg salvianolic acid A (Sal A) for the final 4 weeks