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[PMID: 19616597]

When vitamin B12 levels are low, myelin production can suffer, leading to communication breakdowns in the nervous system

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determined the kinetic parameters of NNMT-catalyzed NAM methylation reaction by using a UHP-HILIC-MS (ultra-high-performance hydrophilic interaction liquid chromatographymass spectrometry) method, in which Km values for NAM and SAM were determined as 200 and 8.5 M, respectively [15]

Peters SU, Kaufmann WE, Bacino CA, Anderson AW, Adapa P, Chu Z, et al

Knowing the right window for supplementation can be the difference between feeling a slight improvement and seeing a noticeable shift in your recovery and clarity