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For the comparison of PLC versus placebo, there was a high level of both clinical and statistical heterogeneity due to study size, participants coming from different countries and centers, the combination of participants with and without diabetes, and the use of different treadmill protocols

Hille, B

The delayed catabolism of BMAT reserves may be advantageous to prolong survival since the average human has approximately 2 to 3 kg of BMAT within the bone marrow

However, despite its widespread use and inclusion on the World Anti-Doping Agency (WADA) prohibited list, there remains a profound lack of high-quality, randomized placebo-controlled trials demonstrating consistent ergogenic benefits in healthy athletes

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